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KMID : 0545120100200030637
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Journal of Microbiology and Biotechnology
2010 Volume.20 No. 3 p.637 ~ p.642
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Nationwide surveillance study of vancomycin intermediate Staphylococcus aureus strains in Korean hospitals from 2001 to 2006
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Chung Gyung-Tae
Cha Jeong-Ok
Han Sun-Young
Jang Hee-Sun
Lee Kyeong-Min
Yoo Jae-Il
Yoo Jung-Sik
Kim Hong-Bin
Eun Soo-Hoon
Kim Bong-Su
Park Ok
Lee Yeong-Seon
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Abstract
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We investigated the prevalence and the molecular characteristics of vancomycin-intermediate Staphylococcus aureus (VISA) among methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from clinical samples at tertiary or general hospitals participating in a nationwide surveillance program for VISA and vancomycin-resistant Staphylococcus aureus (VRSA) in Korea during an 8-week period in each year from 2001 to 2006. Of 41,639 MRSAs isolated, 37,856 were screened and 169 grew on brain heart infusion agar supplemented with 4 mg/L vancomycin. A vancomycin MIC of 4 mg/L was confirmed for 33 VISA isolates of the 169 isolates. Eighteen of the 33 isolates were classified as hetero-VISA (hVISA) by population analysis profile (PAP) method. All VISA isolates were susceptible to linezolid, tigecycline, and quinupristin-dalfopristin Most VISA isolates (MIC 4 mg/L) showed of PFGE C pattern with sec, seg, and sei enterotoxin genes including ST5-SCCmec II or PFGE A pattern with sea, including ST239-SCCmec type III.
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KEYWORD
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Staphylococcus aureus, surveillance, vancomycin, intermediate
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